The eTwinning Project “Awareness of European cultural heritage through innovative and active methodologies” is part of an Erasmus+ KA229 Project which has the same name, being its major motivation based on the necessity of bringing together a number of active and innovative methodologies that are successful in each partner and which share a common basis: the implementation of neurodidactics to education. The current problems in education come from ignoring the learning mechanisms. Boosting the awareness of the European cultural heritage requires the implementation of innovative teaching methodologies and constant renewal. It is necessary to bet on challenges of learning as a factor that motivates the educational renewal of teachers and the interest of pupils. The challenge is to offer pupils a learning in which they become active subjects